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Index > Protein center > HAVCR2(Gene name) > Human
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  • HAVCR2 (Gene name),
  • Hepatitis A virus cellular receptor 2 (Protein name ),  HAVR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Gene name:
    HAVCR2(TIM3;TIMD3);
    Protein name:
    Hepatitis A virus cellular receptor 2(HAVcr-2);
    Alternative:
    T-cell membrane protein 3(TIM-3);T-cell immunoglobulin and mucin domain-containing protein 3(TIMD-3);TIM-3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    301
    Sequence:
    50:
    MFSHLPFDCV | LLLLLLLLTR | SSEVEYRAEV | GQNAYLPCFY | TPAAPGNLVP | 
    100:
    VCWGKGACPV | FECGNVVLRT | DERDVNYWTS | RYWLNGDFRK | GDVSLTIENV | 
    150:
    TLADSGIYCC | RIQIPGIMND | EKFNLKLVIK | PAKVTPAPTR | QRDFTAAFPR | 
    200:
    MLTTRGHGPA | ETQTLGSLPD | INLTQISTLA | NELRDSRLAN | DLRDSGATIR | 
    250:
    IGIYIGAGIC | AGLALALIFG | ALIFKWYSHS | KEKIQNLSLI | SLANLPPSGL | 
    300:
    ANAVAEGIRS | EENIYTIEEN | VYEVEEPNEY | YCYVSSRQQP | SQPLGCRFAM | 
    301:
    P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    MIM:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human HAVcr-2
    Cat.:
    E13657m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human HAVcr-2
    Cat.:
    E13657h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HAVcr-2
    Cat.:
    E13657r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HAVcr-2
    Cat.:
    U13657r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HAVcr-2
    Cat.:
    U13657h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HAVcr-2
    Cat.:
    U13657m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HAVcr-2
    Cat.:
    P13657Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HAVcr-2
    Cat.:
    P13657Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HAVcr-2
    Cat.:
    P13657Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HAVcr-2
    Monoclonal Antibody for Human HAVcr-2
    Monoclonal Antibody for Human HAVcr-2
    Protein for Human HAVcr-2
    Protein for Human HAVcr-2
    Protein for Human HAVcr-2

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    References
    1. 1.
      "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."
      Monney L. , Sabatos C.A. , Gaglia J.L. , Ryu A. , Waldner H. , Chernova T. , Manning S. , Greenfield E.A. , Coyle A.J. , Sobel R.A. , Freeman G.J. , Kuchroo V.K.
      Nature415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LEU-140
    2. 2.
      "Novel human hepatitis A virus cellular receptor."
      Zhang W. , Wan T. , Li N. , Cao X.
      Submitted (2000-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LEU-140
    3. 3.
      "A homolog to human kidney injury molecule-1 is expressed in hepatoma cells."
      Kuehn E.W. , Ichimura T. , Bonventre J.V.
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LEU-140
      tissue: Hepatoma.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-140
      tissue: Embryo.
      tissue: Umbilical cord blood.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-140
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT LEU-140
      tissue: Lung.
      tissue: Pancreas.
    7. 8.
      "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance."
      Sanchez-Fueyo A. , Tian J. , Picarella D. , Domenig C. , Zheng X.X. , Sabatos C.A. , Manlongat N. , Bender O. , Kamradt T. , Kuchroo V.K. , Gutierrez-Ramos J.-C. , Coyle A.J. , Strom T.B.
      Nat. Immunol.4:1093-1101(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 9.
      "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."
      Zhu C. , Anderson A.C. , Schubart A. , Xiong H. , Imitola J. , Khoury S.J. , Zheng X.X. , Strom T.B. , Kuchroo V.K.
      Nat. Immunol.6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR LGALS9
    9. 10.
      "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
      Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-145;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
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